Background: Nowadays, pulseoximetery is one the best and most available methods of detecting patient's arterial blood oxygen saturation; so its normal function is of great importance. Hypothermia, hypotension arid peripheral vasoconstriction can lead to pulseoximeter abnormal function. The present study was carried out over the patients referring to Shahid Modarres hospital since 2000 till 2001 to determine the effect of Digit nerve block on pulseoximetery. Materials and methods: 50 patients over 10 years old, underwent operation longer than 3 hours, had entered this double-blinded sequential clinical trial study. One finger was blocked using 3 cc of marcain 0.5%, where the other finger was just injected saline. Then, both fingers' tip temperature, central temperature, systemic blood pressure, and both fingers' SpO2 were all determined by a person being unaware of the blocked finger. T-test was used for statistical analysis. Results: 50 patients, including 35 males and 15 females, with mean age of 51±17.6 yrs were studied. Favorable functional period of pulseoximetery was 5.8±1.22 and 4.56±1.85 hrs in the case and control group, respectively (p<0.001). In the mean time, mean Digit temperature was recorded 29.31±1.57 and 27.68±1.26 °c in the case and control group, respectively (p<0.001). Conclusion: Digit nerve block seems to be a suitable approach for maintaining normal function in pulseoximetery. Further studies with different drug dosage and greater samples are recommended.